Gene expression profiling may improve diagnosis in patients with carcinoma of unknown primary
نویسندگان
چکیده
منابع مشابه
Cancer of unknown primary or unrecognized adnexal skin primary carcinoma? Limitations of gene expression profiling diagnosis.
TO THE EDITOR: Chiang et al are correct that gene expression profilinginpatientswithcancerofunknownprimary(CUP)canbeuseful and in some instances complements immunohistochemistry in determining the primary cancer site or tissue of origin in these patients. However, thecasepresentedisprobablynotCUP,but illustrateswelloneof the limitations of gene expression profiling in patients with suspected CU...
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Background: Pericardial effusion (PE) due to secondary metastasis has rarely been reported in dogs. Case description: This case describes clinical signs and further diagnostics regarding metastatic carcinoma of unknown primary origin (CUP) in refractory PE of a dog. Findings/treatment and outcome: A nine-year-old, castrated mal...
متن کاملIdentifying the primary site using gene expression profiling in patients with carcinoma of an unknown primary (CUP): a feasibility study from the GEFCAPI.
e22168 Background: CUP are an heterogeneous family of neoplasms with a dismal prognosis, with empiric chemotherapy as the recommended treatment. The aim of this study was to evaluate the feasibility of a 500-mRNA microarray to identify the tissue of origin in patients with CUP. METHODS Diagnostic biopsy formalin-fixed, paraffin-embedded (FFPE) specimens from 22 patients with CUP were prospect...
متن کاملUnknown primary mucoepidermoid carcinoma: diagnosis and treatment.
BACKGROUND Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor. The majority of MECs occur in major or intraoral minor salivary glands. Herein, we present a case of MEC metastatic to cervical lymph nodes with an unknown primary site and discuss diagnostic and treatment options. METHODS AND RESULTS The patient was a 43-year-old man who presented with a large right-...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2008
ISSN: 0007-0920,1532-1827
DOI: 10.1038/sj.bjc.6604315